An inhibitor for Mtb KasA that binds the active site twice
What is it about?
We report GSK3011724A (DG167) as a binary inhibitor of -ketoacyl-ACP synthase (KasA) in Mycobacterium tuberculosis. We show synergy in vitro and in vivo and provide various crystal structures and biochemical data.
Why is it important?
We show that two molecules of DG167 bind in two different sites simultaneously which contradicts the work of GSK published earlier.
The following have contributed to this page: Dr Sean Ekins