Effects of RNA polymerase mutations to fitness defects of rifampicin resistance in bacteria

What is it about?

Antibiotic resistance in bacteria typically result in reduced growth rate, competitive ability and virulence in the absence of antibiotics. This phenomenon is known as the fitness cost of resistance. In this work, we applied a systems biology approach to dissect the molecular mechanisms that contribute to the fitness cost of antibiotic resistance conferred by chromosomal mutations, using rifampicin resistance in the pathogenic bacterium Pseudomonas aeruginosa as a model.

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