Fission yeast resists polyglutamine toxicity.

What is it about?

This paper introduces a fission yeast model expressing polyglutamine expansions. Unlike baker's yeast, fissions yeast does not show any polyglutamine toxicity and reduced aggregation.

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Why is it important?

Our work shows that different organisms (yeasts) have vastly different capacities to manage protein misfolding and its toxicity. The content of misfolding-prone proteins in an organism's proteome cannot serve as a simple predictor for its capacity to prevent protein misfolding and its toxicity.