Global Adaptation to a Lipid Environment Triggers the Dormancy-Related Phenotype of Mycobacterium tuberculosis

What is it about?

We studied the changes in gene expression when the bacterium Mycobacterium tuberculosis was grown with fatty acids as nutrients, given that during infection lipids might be a source of energy for this pathogen. Several genes were identified that reveal mechanisms for adaptation during infection of the human host.

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Why is it important?

This study analyzes changes in M. tuberculosis that might be relevant for the bacterium's long term persistence within the human host. It looks at how this pathogen can adapt to a lipid-enriched environment, which could be relevant during the infectious process.

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