What is it about?
HrpG and HrpV regulate transcription of T3SS in the plant pathogens Pseudomonas syrigae pv. pahseolicola and Erwinia amylovora while HrpJ regulates secretion of middle and late substrates. We have shown that a formed gatekeeper complex among HrpG, HrpV and HrpJ couples the two regulatory mechanisms and maybe responsible for the migration of the transcriptional regulators away from the bacterial chromoso me and close to the bacterial membrane
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Why is it important?
Our results highlight the functional and structural properties of a hitherto-unknown complex which orchestrates intermediate T3SS substrate secretion and may serve as a target for a new class of antibacterials.
Perspectives
This article, apart from the discovery of a hitherto unknown regulatory coupling of mechanisms in phytopathogenic T3SS, came to point out important aspects that need further investigation i.e. there are T3SS substrates that can be exported via T3SS-independent pathways when T3SS is blocked
SPYRIDOULA CHAROVA
IMBB-FORTH
This has been an exciting transnational, interdisciplinary collaboration. I invite more researchers interested in T3SS to join us.
Michael KOKKINIDIS
Foundation for Research & Technology Hellas / IMBB
Read the Original
This page is a summary of: Migration of Type III Secretion System Transcriptional Regulators Links Gene Expression to Secretion, mBio, July 2018, ASM Journals,
DOI: 10.1128/mbio.01096-18.
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