mimicing essential metabolites
What is it about?
This study incorporated identification of putative essential genes and used essential metabolites to search for mimics using chemical similarity for Mycobacterium tuberculosis. We focused on 3 key pathways. We also used pharmacophore searching to identify a couple of molecules that shared molecular similarity with essential metabolites.
Why is it important?
This approach could be used to identify potential chemical probes or starting points for drug discovery efforts. We utilized public data in CDD to identify compounds with apparent similarity to essential metabolites.
The following have contributed to this page: Dr Sean Ekins and Joel Freundlich