Widespread Distribution and Functional Specificity of the Copper Importer CcoA: Distinct Cu Uptake Routes for Bacterial Cytochrome c Oxidases

Bahia Khalfaoui-Hassani, Hongjiang Wu, Crysten E. Blaby-Haas, Yang Zhang, Federica Sandri, Andreia F. Verissimo, Hans-Georg Koch, Fevzi Daldal
  • mBio, February 2018, ASM Journals
  • DOI: 10.1128/mbio.00065-18

First bacterial copper importer prototype

What is it about?

Cytochrome oxidases are membrane-integral cuproproteins that catalyze oxygen reduction to water under hypoxic and normoxic growth conditions. In this study, we show that the copper atoms of the catalytic center of two similar cytochrome c oxidases from this superfamily are provided by different copper uptake systems during their production.

Why is it important?

This finding illustrates different strategies that organisms exhibit to fine-tune the trafficking of copper, which is an essential but toxic micronutrient.

Perspectives

Fevzi Daldal
University of Pennsylvania

This finding is significant as it opens up a road to future research for investigating multiple transition metal (such as copper) uptake pathways for cells.

Read Publication

http://dx.doi.org/10.1128/mbio.00065-18

The following have contributed to this page: Fevzi Daldal

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