Alphavirus, Chikungunya virus nsp2 helicase fidelity variant

What is it about?

Most of what we've known about replication fidelity in RNA viruses come from studies of the viral RNA dependent RNA polymerase. Here, we describe a variant of the nsp2 protease/helicase that also determines replication fidelity, and we show that it better resists the effects of unbalanced intracellular nucleotide concentrations. Our data contribute to a growing body of work indicating that other proteins involved in replication can also determine fidelity and RNA virus mutation rates.

Featured Image

Why is it important?

Our data contribute to a growing body of work indicating that other proteins involved in replication can also determine fidelity and RNA virus mutation rates.