Kaposi's Sarcoma-Associated Herpesvirus ORF45 Mediates Transcriptional Activation of the HIV-1 Long Terminal Repeat via RSK2

J. Karijolich, Y. Zhao, B. Peterson, Q. Zhou, B. Glaunsinger
  • Journal of Virology, April 2014, ASM Journals
  • DOI: 10.1128/jvi.00931-14

Activation of the HIV-1 LTR by KSHV ORF45

What is it about?

Kaposi’s sarcoma-associated herpesvirus (KSHV) is a prominent AIDS-associated pathogen. Previous studies have shown that infection of cells containing human immunodeficiency virus 1 (HIV-1) with KSHV leads to potent stimulation of HIV-1 gene expression by activating the HIV-1 promoter, termed the LTR. Here, we compared the ability of various KSHV proteins to activate gene expression from the HIV-1 LTR and found that KSHV ORF45 is the most potent activator.

Why is it important?

Collectively, our findings provide new insight into the inter-viral interactions between KSHV and HIV that may ultimately impact disease.

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The following have contributed to this page: Britt Glaunsinger

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