An RNA Element in Human Interleukin 6 Confers Escape from Degradation by the Gammaherpesvirus SOX Protein

S. Hutin, Y. Lee, B. A. Glaunsinger
  • Journal of Virology, February 2013, ASM Journals
  • DOI: 10.1128/jvi.00159-13

IL-6 mRNA escapes virus-induced degradation

What is it about?

The herpesviral SOX protein promotes degradation of the majority of host mRNAs--yet some manage to escape. One prominent escapee, the interleukin-6 mRNA, evades destruction through the action of an RNA reguatory element within its 3' UTR. This novel 'SOX resistant element' interacts with multiple cellular proteins and can prevent targeting by the SOX endonuclease even when fused to a heterologous transcript.

Why is it important?

These findings reveal a new mechanism whereby select RNAs may accumulate during viral infection in the background of widespread mRNA destruction.

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