Whole-Genome Multilocus Sequence Typing of Extended-Spectrum-Beta-Lactamase-Producing Enterobacteriaceae

Marjolein F. Q. Kluytmans-van den Bergh, John W. A. Rossen, Patricia C. J. Bruijning-Verhagen, Marc J. M. Bonten, Alexander W. Friedrich, Christina M. J. E. Vandenbroucke-Grauls, Rob J. L. Willems, Jan A. J. W. Kluytmans
  • Journal of Clinical Microbiology, September 2016, ASM Journals
  • DOI: 10.1128/jcm.01648-16

Whole-genome multilocus sequence typing of resistant Gram-negative bacteria

What is it about?

Whole-genome multilocus sequence typing is a new molecular technique to type bacteria. In this paper typing schemes for the most common ESBL-producing Gram-negative bacteria are proposed. In addition, thresholds for genetic distance are proposed that can be used to identify related bacterial isolates in hospital settings.

Why is it important?

This is the first study proposing wgMLST typing schemes for ESBL-producing bacteria and setting thresholds for genetic distance that are based on a large collection of epidemiologically related and unrelated ESBL-producing isolates.

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The following have contributed to this page: Mrs Marjolein Kluytmans and Prof dr. John W Rossen