Rectal Carriage of Extended-Spectrum-Beta-Lactamase-Producing Enterobacteriaceae in Hospitalized Patients: Selective Preenrichment Increases Yield of Screening

M. F. Q. Kluytmans-van den Bergh, C. Verhulst, L. E. Willemsen, E. Verkade, M. J. M. Bonten, J. A. J. W. Kluytmans
  • Journal of Clinical Microbiology, May 2015, ASM Journals
  • DOI: 10.1128/jcm.01251-15

Pre-enrichment increases the yield of screening for carriage with resistant Gram-negative bacteria.

What is it about?

This study evaluated the added value of selective preenrichment for the detection of rectal carriage of extended-spectrum-betalactamase-producing Enterobacteriaceae (ESBL-E). ESBL-E rectal carriage was identified in 4.8% of hospitalized patients, and 25.9% of ESBL-E rectal carriers were identified with selective preenrichment only.

Why is it important?

Appropriate antimicrobial therapy and infection control measures depend on rapid sensitive laboratory detection methods. Without selective pre-enrichment, 25.9 % of ESBL-E carriers and 1.2% of hospitalised patients would not have been identified as ESBL-E carrier, and no contact precautions would have been applied in the care for these patients.

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The following have contributed to this page: Mrs Marjolein Kluytmans

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