Basal Body Structures Differentially Affect Transcription of RpoN- and FliA-Dependent Flagellar Genes in Helicobacter pylori

What is it about?

The bacterial flagellum is an organelle used for motility and is composed of many different types of proteins. Bacteria coordinate the assembly of the flagellum with the synthesis of the flagellar proteins. We show here that knocking out genes for specific flagellar proteins in Helicobacter pylori affect expression (either inhibits or stimulates) of other flagellar proteins.

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Why is it important?

Helicobacter pylori colonizes the human stomach and is the causative agent of peptic ulcers and other gastric diseases. Motility is required for Helicobacter pylori to colonize the stomach. Understanding how Helicobacter pylori controls the synthesis of its flagella could lead to the identification of targets for new therapeutics for treating infections of this significant human pathogen.