What is it about?

CsrA binds to the transcript encoding PNPase and represses translation by inhibiting ribosome binding. CsrA only binds to this transcript after it has been processed by RNase III and PNPase itself.

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Why is it important?

CsrA is a global regulator of gene expression and PNPase is an important enzyme for mRNA degradation. Although CsrA has been shown to regulate translation and mRNA stability of numerous genes in a variety of organisms, this is the first example in which prior mRNA processing is required for CsrA-mediated regulation. Moreover, this work links PNPase expression to conditions affecting CsrA activity.

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This page is a summary of: CsrA Participates in a PNPase Autoregulatory Mechanism by Selectively Repressing Translation ofpnpTranscripts That Have Been Previously Processed by RNase III and PNPase, Journal of Bacteriology, October 2015, ASM Journals,
DOI: 10.1128/jb.00721-15.
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