What is it about?
The sigma factor AlgU activates rsmA expression leading to posttranscriptional activity in mucoid strains of P. aeruginosa that are commonly found in cystic fibrosis patients.
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Why is it important?
This is the first description of RsmA activity in mucoid strains of P. aeruginosa and suggests that RsmA may also have a role in chronic infections.
Perspectives
The fact that alginate regulatory components are involved in activating rsmA expression is surprising. This leads us to speculate that RsmA may have additional targets in mucoid P. aeruginosa strains. We were also surpirsed that the antagonizing small RNAs, RsmY and RsmZ, were also regulated. This begs the question, How does RsmA function in the mucoid strains? Further work is necessary to unravel the full impact of the RsmA/Y/Z system.
Chris Pritchett
East Tennessee State University
Read the Original
This page is a summary of: Pseudomonas aeruginosa AlgU Contributes to Posttranscriptional Activity by IncreasingrsmAExpression in amucA22Strain, Journal of Bacteriology, April 2016, ASM Journals,
DOI: 10.1128/jb.00133-16.
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