What is it about?
We have developed a new method to identify bacterial proteins involved in attachment to human cells. These proteins make very efficacious vaccine antigens. We have proved that this works by protecting mice against Burkholderia infection with a vaccine that we identified as being involved in attachment of Burkholderia to lung cells.
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Why is it important?
It is important for 2 reasons. 1 Burkholderia infections are highly antibiotic resistant and preventing infection with a vaccine would be a better approach than treating an existing infection with antibiotics 2. This method of vaccine antigen identification could be applied to a range of bacterial pathogens for which efficacious vaccines do not currently exist.
Perspectives
The novel adhesins identified have the potential to be very efficacious prophylactic vaccine antigen candidates.
Dr Siobhán McClean
Institute of Technology Tallaght
Read the Original
This page is a summary of: Linocin and OmpW Are Involved in Attachment of the Cystic Fibrosis-Associated Pathogen Burkholderia cepacia Complex to Lung Epithelial Cells and Protect Mice against Infection, Infection and Immunity, February 2016, ASM Journals,
DOI: 10.1128/iai.01248-15.
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