What is it about?
Shigella is a bacteria that causes dysentery. A limitation in Shigella research is that we do not have good systems to study how Shigella interacts with the human intestine. We show that 'mini-intestines' grown in the lab can be used to study how Shigella infects colon tissue.
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Why is it important?
This study provides researchers a new tool to study Shigella pathogenesis.
Perspectives
It was certainly a new experience for me learning how to use intestinal enteroids, but a very good one. I think this is a great system to study Shigella, and I hope others can use this technology to answer important research questions.
Benjamin Koestler
Read the Original
This page is a summary of: Human Intestinal Enteroids as a Model System of Shigella Pathogenesis, Infection and Immunity, January 2019, ASM Journals,
DOI: 10.1128/iai.00733-18.
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