What is it about?
Streptococcus pyogenes produces biofilms in acidic environments. It was not clear why it produces biofilms in acidic environments. It turned out that this bacterium had a mechanism that sensitizes to acidic environments and produces biofilms, which is clarified in this paper.
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Why is it important?
The bacteria were found to have a mechanism that sensitizes them to acidic environments and produces biofilms. The mechanism was a two-component control factor. It was found that acid interacts with sensor proteins and transmits information to biofilm production.
Perspectives
It is known that two-component regulators receive and influence various stimuli in bacteria, etc. This is the first paper to examine the sensitivity of two-component regulators to specific changes, such as acidic environments, and subsequent changes, such as biofilm production, along the way from start to finish.
Masanori Isaka
Read the Original
This page is a summary of: Streptococcus pyogenes TrxSR Two-Component System Regulates Biofilm Production in Acidic Environments, Infection and Immunity, October 2021, ASM Journals,
DOI: 10.1128/iai.00360-21.
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