What is it about?

Bovine viral diarrhea virus (BVDV) is a pestivirus in the family Flaviviridae. BVDV-1 may be further subdivided into more than 15 subgenotypes. BVDV exists in two biotypes, cytopathic (cp) and noncytopathic (ncp), depending on the effect on cultured cells. Solely the ncp biotype is able to generate persistently infected (PI) calves. Such PI calves are at risk of developing fatal mucosal disease (MD), when both biotypes can be isolated that are antigenically closely related, hence referred to as a “virus pair.” The BVDV 1k subgenotype was first described in Switzerland. Here, we determined the first complete genome sequences of both biotypes of a virus pair of BVDV-1k.

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Why is it important?

Compared to the ncp biotype, the cp biotype contains an insertion of 84 nucleotides and 22 nucleotide changes, further supporting a possible hot spot for recombinations at this location in NS2.

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This page is a summary of: Complete Genome Sequences of Both Biotypes of a Virus Pair of Bovine Viral Diarrhea Virus Subgenotype 1k, Genome Announcements, July 2013, ASM Journals,
DOI: 10.1128/genomea.00287-13.
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