What is it about?
We investigate whether the pneumococcal pilus, an important determinant of adhesion and virulence during colonization, pneumonia, and bacteremia, is highly prevalent and genetically diverse in Africa.
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Why is it important?
The findings determine whether pneumococcal conjugate vaccines provide protection/coverage against piliated strains.
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This page is a summary of: Piliation of Invasive Streptococcus pneumoniae Isolates in the Era before Pneumococcal Conjugate Vaccine Introduction in Malawi, Clinical and Vaccine Immunology, September 2013, ASM Journals,
DOI: 10.1128/cvi.00403-13.
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