Probing 3-hydroxyflavone for in vitro glycorandomization of flavonols by YjiC.

What is it about?

The glycosylation of five different flavonols, fisetin, quercetin, myricetin, kaempferol, and 3-hydroxyflavone, was achieved by applying YjiC. 3-Hydroxyflavone was selected as a probe for in vitro glycorandomization of all flavonols using diverse nucleotide diphosphate-d/l-sugars. This study unlocked the possibilities of the glycodiversification of flavonols and the generation of novel compounds as future therapeutics.

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Why is it important?

Glycorandomization of flavonols using versatile glycosyltransferase.