Topo I inhibitors for TB
What is it about?
We used a homology model of Mycobacterium tuberculosis topoisomerase I and docked approved drugs. We identified two novel inhibitors in vitro, imipramine and norclomipramine. The binding of these molecules was characterized through extensive experiments. We propose they bind near the metal binding site of the enzyme
Why is it important?
Small molecule inhibitors of Mtb Topo I had not previously been identified. By finding known drugs it has stimulated the search for similar molecules.
The following have contributed to this page: Dr Sean Ekins