Voriconazole and hypoalbuminemia

What is it about?

Voriconazole shows a large inter- and intrapatient variability in plasma concentrations. Several factors have been identified which can contribute to this variability. However, still lots of patients show sub- and supratherapeutic plasma concentrations and/or treatment failure or adverse events. In this publication, we investigated the impact of hypoalbuminemia on voriconazole pharmacokinetics, because we believe this can be an additional factor influencing voriconazole PK.

Featured Image

Why is it important?

Because of the high mortality rate of invasive fungal infections, adequate treatment is essential. As voriconazole is the first choice in treating invasive aspergillosis, it is very important to elucidate all different factors which can influence variability in voriconazole exposure.