What is it about?
Here we describe the physiological mechanism of treating persistent biofilms of Pseudomonas aeruginosa with the antioxidant Glutathione, a major pathogen in Cystic Fibrosis (CF) and other hospital-acquired infections. We show potential clinical utility for use in combination with antibiotics to reduce overall bacterial load in a specialised media that mimicks CF sputum, the site of long-term infections in individuals with CF.
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Why is it important?
Bacterial biofilms as a structure render traditional antibiotics ineffective due to structural hinderance and chemical inactivation. By disrupting biofilms with novel, non-toxic treatments such as host antioxidants, the protective effects of biofilms are nullified.
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This page is a summary of: Glutathione-Disrupted Biofilms of Clinical Pseudomonas aeruginosa Strains Exhibit an Enhanced Antibiotic Effect and a Novel Biofilm Transcriptome, Antimicrobial Agents and Chemotherapy, May 2016, ASM Journals,
DOI: 10.1128/aac.02919-15.
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