Predicting resistance from whole genome sequencing

What is it about?

Affordable DNA sequencing technologies have made it routine to determine the complete DNA sequence of microorganisms. Theoretically any trait can be inferred from the genomic data. For most antibiotics, resistance in Salmonella can be reliably predicted from the genomic sequence based on known resistance determinants. This provides detailed information on the genes underlying resistance in surveillance systems.

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Why is it important?

Antibiotic resistance surveillance system have historically relied on a series of separate technologies to characterize pathogens and measure resistance to antibiotics. WGS is proving to be a reliable approach for characterizing bacteria In a single workflow, including resistance to antibiotics