What is it about?
About Voriconazole drug levels in plasma after intravenous and oral intake and factors associated with low or toxic plasma concentrations.
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Why is it important?
Multivariate analysis revealed that low VPCs were signifcantly associated with clinical failure of voriconazole, prophylactic use, younger age, underlying hematological malignancy, concomitant protonpump inhibitor, and absence of side effects. Multivariate analysis revealed higher body mass index (BMI), absence of hematological malignancy, therapeutic application, and diarrhea as factors associated with potentially toxic VPCs.
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This page is a summary of: Potential Factors for Inadequate Voriconazole Plasma Concentrations in Intensive Care Unit Patients and Patients with Hematological Malignancies, Antimicrobial Agents and Chemotherapy, April 2013, ASM Journals,
DOI: 10.1128/aac.00251-13.
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