What is it about?
A potent drug for HIV prevention was evaluated for activity in human tissue. Rilpivirine, a potent anti-HIV drug can protect rectal tissues at lower concentrations as compared to cervical tissues. This has important implications for the amount of drug needed at each site to prevent HIV infection.
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Why is it important?
Our findings show about 10-fold more Rilpivirine is needed to prevent vaginal HIV transmission as compared to rectal transmission. Thus persons engaging in receptive vaginal intercourse may need to use Rilpivirine more frequently than those persons engaging in receptive anal intercourse.
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This page is a summary of: Distinct Pharmacodynamic Activity of Rilpivirine in Ectocervical and Colonic Explant Tissue, Antimicrobial Agents and Chemotherapy, February 2016, ASM Journals,
DOI: 10.1128/aac.00167-16.
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