What is it about?

we have shown how the yeast Candida albicans can modulate and adapt to low oxygen levels in different body niches to cause infection and to harm the host.

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Why is it important?

it helps us to understand the pathogenicity of C. albicans and promotes the development of better therapy approaches.

Perspectives

We gained insight into mechanisms which fungal pathogens use to circumvent immune surveillance in environments lacking oxygen. Hence, our study aims for the identification of future therapeutic strategies to reduce premature deaths and to improve patients’ life quality. But fungi are very versatile organisms which can grow at almost any place. Interestingly, growing fungi were spotted at the international space station (ISS). Ongoing research attempts to elucidate how fungal microbes thrive under these conditions. Our investigations open up new avenues to study fungal adaptation to hypoxic environments, such as within our bodies or in space

José Pedro Lopes
Umea Universitet

Read the Original

This page is a summary of: Evasion of Immune Surveillance in Low Oxygen Environments EnhancesCandida albicansVirulence, mBio, November 2018, ASM Journals,
DOI: 10.1128/mbio.02120-18.
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