Lack of AcrB Efflux Function Confers Loss of Virulence on Salmonella enterica Serovar Typhimurium

Xuan Wang-Kan, Jessica M. A. Blair, Barbara Chirullo, Jonathan Betts, Roberto M. La Ragione, Alasdair Ivens, Vito Ricci, Timothy J. Opperman, Laura J. V. Piddock
  • mBio, July 2017, ASM Journals
  • DOI: 10.1128/mbio.00968-17

What is it about?

The AcrB efflux pump in Gram-negative bacteria such as Salmonella spp. gives resistance to many antibiotics. In this study, we show that loss of efflux function causes increased drug susceptibility and loss of ability to infect th host. We also showed that loss of efflux function mutants must be used when assessing the role of MDR efflux pumps and not gene deletion or inactivation mutants.

The following have contributed to this page: Laura JV Piddock