Inosine-Mediated Modulation of RNA Sensing by Toll-Like Receptor 7 (TLR7) and TLR8

  • S. T. Sarvestani, M. D. Tate, J. M. Moffat, A. M. Jacobi, M. A. Behlke, A. R. Miller, S. A. Beckham, C. E. McCoy, W. Chen, J. D. Mintern, M. O'Keeffe, M. John, B. R. G. Williams, M. P. Gantier
  • Journal of Virology, November 2013, ASM Journals
  • DOI: 10.1128/jvi.01571-13

Inosine Modulation of TLR7/8 Sensing

What is it about?

We demonstrate that inosine incorporation into viral RNA can potentiate TLR7/8 activation.

Why is it important?

Our findings indicate that inosine modification of viral RNA by the RNA editing machinery can act to potentiate recognition of viral RNA by TLR7/8 during phagocytosis of infected cells. This is a novel role for A to I RNA editing.

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http://dx.doi.org/10.1128/jvi.01571-13

The following have contributed to this page: Michael Gantier and Professor Bryan R. G. Williams