Inosine Modulation of TLR7/8 Sensing
What is it about?
We demonstrate that inosine incorporation into viral RNA can potentiate TLR7/8 activation.
Why is it important?
Our findings indicate that inosine modification of viral RNA by the RNA editing machinery can act to potentiate recognition of viral RNA by TLR7/8 during phagocytosis of infected cells. This is a novel role for A to I RNA editing.
The following have contributed to this page: Michael Gantier and Professor Bryan R. G. Williams