What is it about?
This study has compared the diagnostic performance of the two targets currently used to amplify Treponema pallidum by PCR: 47kDa protein membrane versus polymerase I gene. We demonstrated that the two targets provide similar accuracy and could be univocally used in routine.
Why is it important?
This is the first study providing a comparison of the diagnostic performance of the two PCRs used in the diagnosis of syphilis on the same samples. This comparison was done on paired samples from a large collection of swabs (n=272). The findings of this study showed the two targets provide the same diagnostic performance and have an almost perfect agreements.
The following have contributed to this page: Dr Angèle Gayet-Ageron
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