AtlA Mediates Extracellular DNA Release, Which Contributes to Streptococcus mutans Biofilm Formation in an Experimental Rat Model of Infective Endocarditis

Chiau-Jing Jung, Ron-Bin Hsu, Chia-Tung Shun, Chih-Chieh Hsu, Jean-San Chia
  • Infection and Immunity, July 2017, ASM Journals
  • DOI: 10.1128/iai.00252-17

AtlA mediating eDNA release contributes to infective endocarditis

What is it about?

Infective endocarditis is a biofilm-related infetious disease and refractory to antibiotic treatment. This study demonstrated the AtlA, autolysin of S. mutans, contributes to bacterial extracellular DNA release, which facilitate to biofilm formation on the damaged valve of experimental endocarditis rats.

Why is it important?

Our finding demonstrated the role of bacterial AtlA and eDNA in the pathogenesis of IE. It provides important important information in the pathogenesis of IE.

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The following have contributed to this page: Professor Jean-San Chia and Chiau-Jing Jung