Draft Genome Sequence of the Vaginal Isolate Corynebacterium amycolatum ICIS 9

  • Irina V. Gladysheva, Yuriy A. Khlopko, Sergey V. Cherkasov
  • Genome Announcements, September 2017, ASM Journals
  • DOI: 10.1128/genomea.00975-17

Biosurfactants producing non-pathogenic strains Corynebacterium spp.

What is it about?

Corynebacterium amycolatum ICIS 9 was isolated from a vaginal smear of a healthy woman. Here, we report the draft genome sequence of C. amycolatum ICIS 9, which will be useful for further studies of specific genetic features of this strain and for understanding its probiotic properties.

Why is it important?

The genus Corynebacterium spp., also known as "diphtheroids" or "coryneform" includes more than 88 species. Of these, 53 species are occasional or extremely rare causes of diphtheria and diphtheria-like diseases in humans or are transmitted to humans by zoonotic contact. Along with the fact that microorganisms of the genus Corynebacterium play a role in the development of infection in humans, recently, the information about the important role of individual representatives of this group of microorganisms in the formation of microbiocenosis of different biotopes of the human body. Is no exception and the reproductive tract of women, where corynebacteria, according to some researchers, along with lactobacilli play an important role in maintaining colonization resistance. Along with the fact that non-pathogenic corynebacteria have their own antagonistic activity against pathogenic and conditionally pathogenic microorganisms, they potentiate the antagonistic activity of peroxide producing lactobacilli that probably is one of the key mechanisms for the protection of the reproductive tract of women from the development of infections.


Irina Gladysheva
Institute for Cellular and Intracellular Symbiosis, Ural Branch of Russian Academy of Sciences

This project includes the non-pathogenic strains Corynebacterium spp. isolated from the reproductive tract of healthy women which has a good probiotic properties, due to the production of surfactants (biosurfactants) and increased antagonist activity of peroxide producing lactobacilli in relation to opportunistic pathogens.

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The following have contributed to this page: Irina Gladysheva