Immune Evasion, Stress Resistance, and Efficient Nutrient Acquisition Are Crucial for Intracellular Survival of Candida glabrata within Macrophages

  • Katja Seider, Franziska Gerwien, Lydia Kasper, Stefanie Allert, Sascha Brunke, Nadja Jablonowski, Tobias Schwarzmüller, Dagmar Barz, Steffen Rupp, Karl Kuchler, Bernhard Hube
  • Eukaryotic Cell, December 2013, ASM Journals
  • DOI: 10.1128/ec.00262-13

Immune evasion is key for C. glabrata virulence

What is it about?

Candida glabrata is both a human fungal commensal and an opportunistic pathogen which can withstand activities of the immune system. For example, C. glabrata can survive phagocytosis and replicates within macrophages. However, the mechanisms underlying intracellular survival remain unclear. In this work, we used a functional genomic approach to identify C. glabrata determinants necessary for survival within human monocyte-derived macrophages by screening a set of 433 deletion mutants. We identified and characterised 23 genes which are required to resist killing by macrophages.

Why is it important?

Our data support the view that immune evasion is a key aspect of C. glabrata virulence and that increased immune recognition causes increased antifungal activities by macrophages. Furthermore, stress resistance and efficient nutrient acquisition, in particular, iron uptake, are crucial for intraphagosomal survival of C. glabrata.

Perspectives

Bernhard Hube

Our data show that immune evasion, stress resistance, and efficient nutrient acquisition, in particular iron, are crucial for intracellular survival of Candida glabrata within macrophages

Read Publication

http://dx.doi.org/10.1128/ec.00262-13

The following have contributed to this page: Bernhard Hube

Contributors