Piliation of Invasive Streptococcus pneumoniae Isolates in the Era before Pneumococcal Conjugate Vaccine Introduction in Malawi

Benard W. Kulohoma, Katherine Gray, Arox Kamng'ona, Jennifer Cornick, Stephen D. Bentley, Robert S. Heyderman, Dean B. Everett
  • Clinical and Vaccine Immunology, September 2013, ASM Journals
  • DOI: 10.1128/cvi.00403-13

Do invasive Streptococcus pneumoniae in Africa have pilus?

What is it about?

We investigate whether the pneumococcal pilus, an important determinant of adhesion and virulence during colonization, pneumonia, and bacteremia, is highly prevalent and genetically diverse in Africa.

Why is it important?

The findings determine whether pneumococcal conjugate vaccines provide protection/coverage against piliated strains.

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http://dx.doi.org/10.1128/cvi.00403-13

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