What is it about?
Engineering yeast to make malic acid from glucose
Why is it important?
Engineering of yeast for the production of C4-dicarboxylic acids (malate, succinate) is of great industrial interest. This paper is, to my knowledge, the first demonstration that successful engineering of yeast for production of these compounds requires the combined overexpression of a carboxylating enzyme, an oxidoreductase and, importantly, an exporter.
The following have contributed to this page: Dr Rintze M Zelle and Prof Jack T Pronk