What is it about?

Creating natural product based antidote against botulism

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Why is it important?

Botulism is a dreaded disease that causes flaccid paralysis. Botulinum neurotoxins which cause botulism are dreaded biothreat, bioterrorism, and food poisoning agents. In addition, patients who use botulinum neurotoxin as therapeutics may get adverse effects. Currently, no antidote of botulism exists, making this discovery very critical development.


One of the authors (Bal Ram Singh) has background in Ayurveda, the traditional herbal medicine system of India. The idea of using natural products originated from there, and led to the contacts with colleagues at the Chemistry department in Delhi University. The lead author (Kruti Patel) was excited to try the system of herbs for drug development for her PhD dissertation.

Bal Ram Singh
Institute of Advanced Sciences

Read the Original

This page is a summary of: Natural Compounds and Their Analogues as Potent Antidotes against the Most Poisonous Bacterial Toxin, Applied and Environmental Microbiology, November 2018, ASM Journals,
DOI: 10.1128/aem.01280-18.
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