Nanoscale Effects of Caspofungin against Two Yeast Species, Saccharomyces cerevisiae and Candida albicans

  • C. Formosa, M. Schiavone, H. Martin-Yken, J. M. François, R. E. Duval, E. Dague
  • Antimicrobial Agents and Chemotherapy, May 2013, ASM Journals
  • DOI: 10.1128/aac.00105-13

Caspofungin modifies candida and saccharomyces cell wall

What is it about?

The paper is about the cell wall of 2 yeasts species: Candida albicans and Saccharomyces cerevisiae. We explored the cell modifications induced by the antifungal drug: Caspofungin.

Why is it important?

Candida albicans is a widespread opportunistic pathogen, that can be dangerous to immunodeficient patients. Understanding the mechanism of action of Caspofungin, a last chance molecule, is therefore of first importance

Perspectives

Etienne Dague

The next step would be to analyze the effect of caspofungin on adhesins expressed by candida albicans.

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http://dx.doi.org/10.1128/aac.00105-13

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