A dynamic nuclear actin cytoskeleton in living cells

What is it about?

Existence of signal-operated, dynamic nuclear actin polymerisation. Nuclear actin assembly as a critical step in the regulation of MAL (MRTF) and serum response factor (SRF). A nuclear function for Diaphanous formins (formin homology proteins, DRFs).

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Why is it important?

A new dimension of the structure and organisation of the mammalian nucleus. The ability of intact living cells to respond to extracellular cues with actin assembly in the nucleus. First concept for spatiotemporally and reversibly regulating intramolecular autoinhibition of endogenous proteins using light (optogenetic tool).