What is it about?
Natural skin structure has appendage organs such as hair follicle, dermis, sebaceous gland, and sweat gland and subcutaneous adipose tissue. These components play important roles to maintain homeostasis including moisturization, fat secretion and protect for noxious stimulations. This bioengineered 3D integumentary organ system was fully functional following transplantation into immunodeficient mice and could be properly connected to surrounding host tissues, such as the epidermis, arrector pili muscles and nerve fibres, without tumorigenesis.
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Why is it important?
Organ generation, which is a complex process of organogenesis during embryogenesis, is a next-generation of regenerative medicine. In our study, we succeed to reproduce of skin development during embryo genesis and regenerate skin field, 3D integumentary system including skin appendages from iPS cells.
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This page is a summary of: Bioengineering a 3D integumentary organ system from iPS cells using an in vivo transplantation model, Science Advances, April 2016, American Association for the Advancement of Science,
DOI: 10.1126/sciadv.1500887.
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