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Why is it important?
The multiple tautomerization occurred in the enzyme is observed in asparagine residues and peptide bonds around the catalytic residue. This is very important finding not only for cellulase but also for general proteins because this phenomenon has not been taken into account in usual computational simulation of proteins used for drug design, etc.
Perspectives
There are more than 100,000 structures are available in protein data bank, while only less than 90 protein structures have been solved by Neutron crystallography. We suggest the importance of the technique, which can visualize hydrogen and proton in proteins, in addition to typical X-ray structure.
Professor Kiyohiko Igarashi
Tokyo Daigaku
Read the Original
This page is a summary of: "Newton's cradle" proton relay with amide-imidic acid tautomerization in inverting cellulase visualized by neutron crystallography, Science Advances, August 2015, American Association for the Advancement of Science,
DOI: 10.1126/sciadv.1500263.
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