Lack of Influence of Substrate on Ligand Interaction with the Human Multidrug and Toxin Extruder, MATE1

  • Lucy J. Martínez-Guerrero, Mark Morales, Sean Ekins, Stephen H. Wright
  • Molecular Pharmacology, July 2016, American Society for Pharmacology & Experimental Therapeutics (ASPET)
  • DOI: 10.1124/mol.116.105056

MATE1 structure activity relationships

What is it about?

Multidrug and toxin extruder 1 (MATE1) is a transporter with aq key role in renal secretion of organic cations. This study tested over 400 drugs to access whether they interacted with this transporter using 4 different substrates. this data was used to build pharmacophores and bayesian models for each dataset.

Why is it important?

This work is relevant as there has been much discussion in the field about substrate dependent interactions. It would appear from the data and models created that with these 4 substrate probes there is no difference - such that substrate identity has little impact on interaction with this transporter.

Perspectives

Dr Sean Ekins
Collaborations in Chemistry

This represents the latest in a long standing collaboration with the Wright lab at the University of Arizona. Again it features a combination of in vitro and computational apporaches. Unlike transporters such as OCT2, substrate dependence does not appear to be key with MATE1.

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http://dx.doi.org/10.1124/mol.116.105056

The following have contributed to this page: Dr Sean Ekins