MATE1 structure activity relationships
What is it about?
Multidrug and toxin extruder 1 (MATE1) is a transporter with aq key role in renal secretion of organic cations. This study tested over 400 drugs to access whether they interacted with this transporter using 4 different substrates. this data was used to build pharmacophores and bayesian models for each dataset.
Why is it important?
This work is relevant as there has been much discussion in the field about substrate dependent interactions. It would appear from the data and models created that with these 4 substrate probes there is no difference - such that substrate identity has little impact on interaction with this transporter.
The following have contributed to this page: Dr Sean Ekins