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This paper shows that a hypothalamic peptide orexin-B is capable of promoting the survival of midbrain dopamine neurons, alone or in cooperation with nicotine.

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This page is a summary of: The Sleep-Modulating Peptide Orexin-B Protects Midbrain Dopamine Neurons from Degeneration, Alone or in Cooperation with Nicotine, Molecular Pharmacology, December 2014, American Society for Pharmacology & Experimental Therapeutics (ASPET),
DOI: 10.1124/mol.114.095703.
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