What is it about?
The study examines how a set of zwitterionic oximes cross the blood-brain barrier and are effective in reversing the central manifestations of organophosphate toxicity resulting from terrorism and improper use of pesticides. A loading and maintenance dose scheme is presented for these antidotes that should be useful in counteracting terrorism and treating organophosphate-exposed individuals in field and hospital emergency settings.
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Why is it important?
Development of antidotes to chemical terrorism or agents of toxicity will counteract terrorism and provide antidotes in emergency field situations. Because of limitations on distribution of antidotes and their stability, small molecules that are rapid acting after parenteral administration (intramuscular) offer the greatest hope and potential.
Perspectives
A new class of compounds is offered that do not carry the limitations of quaternary aldoximes that poorly pass the blood-brain barrier.
Palmer Taylor
University of California, San Diego
Read the Original
This page is a summary of: Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure, Journal of Pharmacology and Experimental Therapeutics, September 2018, American Society for Pharmacology & Experimental Therapeutics (ASPET),
DOI: 10.1124/jpet.118.249383.
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