What is it about?
This work is about a animal model using radio telemetry to study the effects of chronic glucocorticoid oral administration on blood pressure and heart rate. Moreover, it shows the impact of glucocorticoid administration on the expression of tyrosine hydroxylase, the rate-limiting enzyme of catecholamine synthesis.
Featured Image
Why is it important?
This model is useful to further dissect out the role of the sympathetic nervous system on glucocorticoid-induced hypertension.
Perspectives
This is a important contribution to the mechanisms involved in glucocorticoid-induced hypertension because this work is a representation of system biology, placing together molecular and physiological approaches to explain more precisely the effects of glucocorticoids on the cardiovascular system.
Alexandra Soto
Universidad Autonoma del Estado de Mexico
Read the Original
This page is a summary of: A Novel Model of Dexamethasone-Induced Hypertension: Use in Investigating the Role of Tyrosine Hydroxylase, Journal of Pharmacology and Experimental Therapeutics, July 2016, American Society for Pharmacology & Experimental Therapeutics (ASPET),
DOI: 10.1124/jpet.116.234005.
You can read the full text:
Contributors
The following have contributed to this page
