What is it about?
Patients usually receive opioid as pain killer, but they may suffered more pain after using of opioids, this phenomenal called opioid induced Hyperalgesia (OIH). The reason for OIH is not fully revealed. We found a central nervous part named amygdala can modulate OIH through a molecular CaMKII. This new find may facilitate exploring new treatment for OIH in the future.
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Why is it important?
Most of current studies about OIH focused on peripheral mechanism, but OIH can not be fully explained by peripheral mechanism. Our find first proved there is a central mechanism for OIH. The location of this central modulation is amygdala. The key molecular is CaMKII.
Perspectives
The reason for OIH is not fully revealed. We found a central nervous part named amygdala can modulate OIH through a molecular CaMKII. This new find propose a new question about how this mechanism differ from the modulation of other type of pain. If we found the answer in the future, it may facilitate exploring new treatment for OIH.
Fang Luo
Huazhong University of Science and Technology
Read the Original
This page is a summary of: Inhibition of CaMKII in the Central Nucleus of Amygdala Attenuates Fentanyl-Induced Hyperalgesia in Rats, Journal of Pharmacology and Experimental Therapeutics, July 2016, American Society for Pharmacology & Experimental Therapeutics (ASPET),
DOI: 10.1124/jpet.116.233817.
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