Experimental and Computational approaches for MATE1 and MATE2-K
What is it about?
MATEs are transporters involved in organic cation secretion. 59 compounds were evaluated as inhibitors and subsets of these were used to build and test pharmacophores for MATE1. $6 compounds were used to build Bayesian models for both transporters.
Why is it important?
We defined pharmacophores for MATE1 and also suggested we might see differences in the pharmacophore depending on the Substrate probe used e.g. ASP vs MPP.
The following have contributed to this page: Dr Sean Ekins