What is it about?
Coumadin is an anticoagulant drug consisting of two mirror images of the molecule warfarin (chirality) that is used as a mixture worldwide to treat blood clotting disorders. Warfarin metabolism determines how fast the drug leaves the body and how much of its metabolites are left to contribute to anticoagulation. The publication provides critical information about how the chirality of the drug in two forms makes certain metabolic pathways more efficient than others.
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Why is it important?
The differences in warfarin metabolism could impact the overall levels of active forms of the drug in patients and hence, the responses to the drug. A more in depth understanding of that relationship could decrease adverse drug effects and improve safety during medication.
Perspectives
This work highlights the value of carefully designed experiments to deconvolute seemingly complex processes like the metabolism of mirror images of the same drug.
Grover P Miller
University of Arkansas for Medical Sciences
Read the Original
This page is a summary of: Stereospecific Metabolism of R- and S-Warfarin by Human Hepatic Cytosolic Reductases, Drug Metabolism and Disposition, June 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET),
DOI: 10.1124/dmd.117.075929.
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