Mass spectrometric responses of drugs and metabolites

What is it about?

This investigation has shown that the practice of using parent drug response to quantify metabolites should be used with caution.

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Why is it important?

For many researchers, it is tempting to pursue this practice of semiquantification in early drug discovery and even preclinical development, when radiolabeled ADME studies are being deferred to later stages of drug development. The caveats of quantifying metabolites based on parent drug response are explored in this investigation.