Transporters on Arachnoid barrier cells
What is it about?
Arachinoid cells form part of the blood-CSF barrier. Until this work the transporters on them had not been examined and neither had theri influence on drug disposition.
Why is it important?
Drugs are administered in the CSF and drug concentrations here are used as a surrogate for brain concentrations. In mouse Pgp and BCRP were found in these cells. The cells also expressed other transporters and drug metabolizing enzymes.
The following have contributed to this page: Dr Sean Ekins and Dr Peter Vogel